Hauptfolge Dezember – Folge 84

Zum Jahresende haben wir was ganz Besonderes für euch: Wir haben uns live und in Farbe im schönen Sauerland getroffen um diese Folge für euch aufzunehmen. Wie jedes Jahr gibt es wieder einen XXXXL-Journalclub für euch. Außerdem stellt Dana die Neuerungen der Reanimationsguidelines 2025 vor und Anna-Lena spricht über das wahnsinnig spannende und relevante Thema „Gendermedizin in der Anästhesie“. Wir hoffen, ihr habt genauso viel Spaß beim Hören wie wir bei der Aufnahme!

Wir wünschen euch ganz viel Spaß beim Hören und einen guten Rutsch ins Jahr 2026!

Vermischtes – Reanimation

https://www.erc.edu/science-research/guidelines/guidelines-2025

Journal Club

Henning:

Kaufman M, Jahr JS, Klompas AM, Perelman S, Raphael J, Tan GM, Frank SM, Waters JH, Warner MA. Exploring Myths of Perioperative Autologous Red Blood Cell Salvage. Anesthesiology. 2025 Nov 1;143(5):1357-1370. doi: 10.1097/ALN.0000000000005586. Epub 2025 Sep 15. PMID: 40951985; PMCID: PMC12440369.

Paula:

Jung B, Jabaudon M, De Jong A, Bitker L, Audard J, Klouche K, Sarton B, Guitton C, Lasocki S, Rieu B, Canet E, Jeantrelle C, Roquilly A, Mayaux J, Verdonk F, Pottecher J, Ferrandiere M, Riu B, Garcon P, Assefi M, Detouche P, Forel JM, Roger C, Bourenne J, Jacquier S, Bougon D, Rolle A, Corne P, Benchabane N, Richard JC, Asehnoune K, Chanques G, Reignier J, Belafia F, Fosset M, Huguet H, Futier E, Molinari N, Jaber S; BICARICU-2 Study Group. Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury: The BICARICU-2 Randomized Clinical Trial. JAMA. 2025 Dec 9;334(22):2000-2010. doi: 10.1001/jama.2025.20231. PMID: 41159812; PMCID: PMC12573113.

Wong CX, Cheung CC, Montenegro G, Oo HH, Peña IJ, Tang JJ, Tu SJ, Wall G, Dewland TA, Moss JD, Gerstenfeld EP, Tseng ZH, Hsia HH, Lee RJ, Olgin JE, Vedantham V, Scheinman MM, Lee C, Sanders P, Marcus GM. Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: The DECAF Randomized Clinical Trial. JAMA. 2025 Nov 9:e2521056. doi: 10.1001/jama.2025.21056. Epub ahead of print. PMID: 41206802; PMCID: PMC12598581.

Ines:

Fortier LM, Moyal AJ, Dave U, Burkhart RJ, Adelstein JM, Strony JT, Sinkler M, Napora J. Serotonergic antidepressants are associated with increased acute bleeding events following femur fracture fixation: A nationwide matched cohort analysis of 5,477 patients. Injury. 2025 Apr;56(4):112236. doi: 10.1016/j.injury.2025.112236. Epub 2025 Mar 8. PMID: 40073712

Anna-Lena

Spangaro, J., Vajda, J., Klineberg, E., Lin, S., Griffiths, C., Saberi, E., Field, E., Miller, A., & McNamara, L. (2020). Intimate partner violence screening and response in New South Wales emergency departments: A multi-site feasibility study. Emergency Medicine Australasia, 32(4), 548-555. https://doi.org/https://doi.org/10.1111/1742-6723.13452

Thorben

Gendermedizin in der Anästhesie

Physiologie ​(Diego, 2023; Morelli et al., 2004; Stachenfeld & Taylor, 2004)

Awareness ​(Braithwaite et al., 2023; Wasilczuk et al., 2024)

PONV ​​(Krieser, 2020)

Herz ​​(de Marvao et al., 2021; Diego, 2023; Ohkuma et al., 2019)

Wärme ​(Lee et al., 2022)

Sepsis ​(Merdji et al., 2023; Zimmermann et al., 2024)

TBI​​(Valera et al., 2021)

Thoraxschmerz (de Marvao et al., 2021; Settelmeier et al., 2024)

Reanimation ​(Blom et al., 2019; Catalisano et al., 2025)

Schmerz ​(Diego, 2023; Filipescu & Ştefan, 2021; Guzikevits et al., 2024; Mohammad Aghaei et al., 2024)

Literaturverzeichnis

Blom, M. T., Oving, I., Berdowski, J., van Valkengoed, I. G. M., Bardai, A., & Tan, H. L. (2019). Women have lower chances than men to be resuscitated and survive out-of-hospital cardiac arrest. Eur Heart J, 40(47), 3824-3834. https://doi.org/10.1093/eurheartj/ehz297

Braithwaite, H. E., Payne, T., Duce, N., Lim, J., McCulloch, T., Loadsman, J., Leslie, K., Webster, A. C., Gaskell, A., & Sanders, R. D. (2023). Impact of female sex on anaesthetic awareness, depth, and emergence: a systematic review and meta-analysis. Br J Anaesth,131(3), 510-522. https://doi.org/10.1016/j.bja.2023.06.042

Catalisano, G., Ippolito, M., Spina, N., Iozzo, P., Galvano, A. N., Giarratano, A., & Cortegiani, A. (2025). Association between bystander cardiopulmonary resuscitation initiation and patient’s sex: a systematic review and meta-analysis. Resusc Plus, 22, 100916. https://doi.org/10.1016/j.resplu.2025.100916

de Marvao, A., Alexander, D., Bucciarelli-Ducci, C., & Price, S. (2021). Heart disease in women: a narrative review. Anaesthesia, 76 Suppl 4, 118-130. https://doi.org/10.1111/anae.15376

Diego, L. (2023). Anesthesia and women’s peculiarities. Rev Assoc Med Bras (1992), 69(suppl 1), e2023S2103. https://doi.org/10.1590/1806-9282.2023S103

Filipescu, D., & Ştefan, M. (2021). Sex and gender differences in anesthesia: Relevant also for perioperative safety? Safety and Quality in Perioperative Anesthesia Care,35(1), 141-153. https://doi.org/https://doi.org/10.1016/j.bpa.2020.12.006

Guzikevits, M., Gordon-Hecker, T., Rekhtman, D., Salameh, S., Israel, S., Shayo, M., Gozal, D., Perry, A., Gileles-Hillel, A., & Choshen-Hillel, S. (2024). Sex bias in pain management decisions. Proc Natl Acad Sci U S A,121(33), e2401331121. https://doi.org/10.1073/pnas.2401331121

Krieser. (2020). PONV Prophylaxis Failure Disproportionately Affects Female Patients, Despite Intraoperative Computerized Decision Support Guidance. Graduate Medical Education Research Journal, 2(1). https://doi.org/10.32873/unmc.dc.gmerj.2.1.091

Lee, C., Lee, J., Lee, G., Park, S., Lee, M., & Kim, H. (2022). Impact of the Hormonal Status in Women on Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery when Considering the Fresh Gas Flow Rate: A Retrospective Study. Biomed Res Int, 2022, 5305165. https://doi.org/10.1155/2022/5305165

Merdji, H., Long, M. T., Ostermann, M., Herridge, M., Myatra, S. N., De Rosa, S., Metaxa, V., Kotfis, K., Robba, C., De Jong, A., Helms, J., & Gebhard, C. E. (2023). Sex and gender differences in intensive care medicine. 49(10), 1155-1167. https://doi.org/10.1007/s00134-023-07194-6

Mohammad Aghaei, A., Urban Spillane, L., Pittman, B., Flynn, L. T., De Aquino, J. P., Bassir Nia, A., & Ranganathan, M. (2024). Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study. 241(10), 2145-2155. https://doi.org/10.1007/s00213-024-06625-6

Morelli, C., Badr, M. S., & Mateika, J. H. (2004). Ventilatory responses to carbon dioxide at low and high levels of oxygen are elevated after episodic hypoxia in men compared with women. J Appl Physiol (1985), 97(5), 1673-1680. https://doi.org/10.1152/japplphysiol.00541.2004

Ohkuma, T., Komorita, Y., Peters, S. A. E., & Woodward, M. (2019). Diabetes as a risk factor for heart failure in women and men: a systematic review and meta-analysis of 47 cohorts including 12 million individuals. 62(9), 1550-1560. https://doi.org/10.1007/s00125-019-4926-x

Settelmeier, S., Ahrens, I., Giannitsis, E., Neumann, J. T., Post, F., Steven, S., & Breuckmann, F. (2024). Diagnostische Strategien in der frühhospitalen Abklärung des akuten Thoraxschmerzes: Arbeitsgruppenpapier der AG 44 Akuter Thoraxschmerz. Die Kardiologie, 18(4), 322-330. https://doi.org/10.1007/s12181-024-00696-7

Spangaro, J., Vajda, J., Klineberg, E., Lin, S., Griffiths, C., Saberi, E., Field, E., Miller, A., & McNamara, L. (2020). Intimate partner violence screening and response in New South Wales emergency departments: A multi-site feasibility study. Emergency Medicine Australasia, 32(4), 548-555. https://doi.org/https://doi.org/10.1111/1742-6723.13452

Stachenfeld, N. S., & Taylor, H. S. (2004). Effects of estrogen and progesterone administration on extracellular fluid. Journal of Applied Physiology, 96(3), 1011-1018. https://doi.org/10.1152/japplphysiol.01032.2003

Valera, E. M., Joseph, A. C., Snedaker, K., Breiding, M. J., Robertson, C. L., Colantonio, A., Levin, H., Pugh, M. J., Yurgelun-Todd, D., Mannix, R., Bazarian, J. J., Turtzo, L. C., Turkstra, L. S., Begg, L., Cummings, D. M., & Bellgowan, P. S. F. (2021). Understanding Traumatic Brain Injury in Females: A State-of-the-Art Summary and Future Directions. J Head Trauma Rehabil, 36(1), E1-E17. https://doi.org/10.1097/HTR.0000000000000652

Wasilczuk, A. Z., Rinehart, C., Aggarwal, A., Stone, M. E., Mashour, G. A., Avidan, M. S., Kelz, M. B., Proekt, A., & Re, C. S. G. (2024). Hormonal basis of sex differences in anesthetic sensitivity. Proc Natl Acad Sci U S A,121(3), e2312913120. https://doi.org/10.1073/pnas.2312913120

Zimmermann, T., Kaufmann, P., Amacher, S. A., Sutter, R., Loosen, G., Merdji, H., Helms, J., Todorov, A., Gebert, P., Regitz-Zagrosek, V., Gebhard, C., Singer, M., Siegemund, M., Gebhard, C. E., & Swiss, I. C. U. T. g. (2024). Sex differences in the SOFA score of ICU patients with sepsis or septic shock: a nationwide analysis. Crit Care, 28(1), 209. https://doi.org/10.1186/s13054-024-04996-y